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KMID : 0978920110120020142
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Korean Journal of Clinical Geriatrics
2011 Volume.12 No. 2 p.142 ~ p.149
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Pulmonary Dysfunction in Parkinson’s Disease
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Lee Seung-Hwan
Choi Youn-Seon
Koh Seung-Beom
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Abstract
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Background: Motor deficits associated with Parkinson’s disease (PD) have been well described, yet little attention has been paid to non-motor miscellaneous symptoms. In this study, we identified pulmonary dysfunction in patients with PD. We also investigated the relationship between pulmonary function and parkinsonian motor signs.
Methods: A total 76 patients were recruited. We enrolled 33 patients with tremor dominant (TD) PD patients and 43 patients with postural instability and gait disturbances dominant (PIGD) PD patients without symptoms of pulmonary dysfunction. A pulmonary function test (PFT) was performed in all patients. The Hoehn & Yahr stage was determined and the degree of disease severity was quantified by activities of daily living and motor score of the Unified Parkinson’s Disease Rating Scale (UPDRS).
Results: There was no significant difference in PFT between patients with TD motor abnormalities and patients with PIGD. Individual clinical disability scales showed a strong negative correlation with forced vital capacity (FVC) and volume of air expired during the first second of the FVC test (FEV1) (P＜0.05). The FEV1/FVC ratio showed a significant correlation with motor score of the UPDRS and the Hoehn-Yahr stage.
Conclusion: We suggest that the FVC and FEV1 could reflect a subject’s clinical disability regardless of dominant clinical features. Additionally, the FEV1/FVC ratio could be an indicator for motor score of the UPDRS or disease stages in general. Therefore, we suggest that PFT could be used to evaluate the clinical disability of patients with PD or prevent them from developing pulmonary complications.
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KEYWORD
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Parkinson’s disease, Pulmonary function test
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